Ammonia methanol → HCID 59596673, compound

Participants

Reaction Steps

A solution of ethyl 6-(4-{[(3-fluorophenyl)methyl]oxy}phenyl)-2-pyridinecarboxylate (D3, 110 mg, 0.30 mmol) in MeOH/NH3 (7M, 5 ml) was stirred at 60° C. in a sealed tube for 6 h. The solvent was then evaporated under reduced pressure to afford the title compound (95 mg); MS: (ES/+) m/z: 323 [MH+], C19H15FNO3 requires 322; 1H-NMR (300 MHz, DMSO) δ (ppm): 8.25 (bs, 2H), 8.20 (d, 1H), 8.05 (d, 1H), 7.95 (t, 1H), 7.85 (d, 1H), 7.65 (bs, 1H), 7.40 (t, 1H), 7.30 (d, 2H), 7.15 (t, 1H), 7.10 (d, 2H), 5.20 (s, 2H).

Provenance & Evidence