Methanol → HCID 59164851, compound

Participants

Reaction Steps

To a solution of methyl (5R)-5-{4-[(phenylmethyl)oxy]phenyl}-L-prolinate (D8, 120 mg, 0.38 mmol) in THF (2.3 ml) was added LiOH monohydrate (26 mg, 0.61 mmol) dissolved in water (1.1 ml) followed by methanol (1.1 ml). The resulting solution was stirred at room temperature for 3 hours (hydrolysis being monitored by HPLC). When hydrolysis was complete, the organic solvent was evaporated under reduced pressure (maintaining the temperature at 38° C.) to give a crude aqueous residue containing the title compound; Rt (HPLC)=3.63 min; MS: (ES/+) m/z: 298 [MH+], C18H19NO3 requires 297).

Provenance & Evidence