Potassium Carbonate → 4-Bromo-3-fluorophenyl (2-fluorophenyl)methyl ether

関与物質

反応手順

A solution of 4-bromo-3-fluorophenol (5 g, 25 mmol), 2-fluorobenzylbromide (4.94 g, 26 mmol) and potassium carbonate (5.39 g, 39 mmol) was stirred at room temperature for 6 h. The solvent was evaporated, the residue taken up in water and extracted with ethyl acetate. The combined organic layers were dried over Na2SO4, filtered and evaporated under reduced pressure, affording the title compound (8.11 g) as a white solid; Rt (HPLC) 6.31 min.

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