1-(Benzyloxy)-3-bromobenzene → HCID 59468912, compound

HRID 2264810Notes

Reaction equation

HRID 2264810 reaction equation
[O:1]=[C:2]1[N:6]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[C@H:5]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][CH2:3]1.[C:18]1([CH2:24][O:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28](Br)[CH:27]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:11][C:10]([O:9][C:7]([NH:6][C@@H:5]([CH2:4][CH2:3][C:2](=[O:1])[C:30]1[CH:29]=[CH:28][CH:27]=[C:26]([O:25][CH2:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:31]=1)[C:14]([O:16][CH3:17])=[O:15])=[O:8])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 27566381-(Benzyloxy)-3-bromobenzeneHCID 108684851-O-tert-butyl 2-O-methyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

Product 1

HCID 59468912HCID 59468912, compound

Procedure

The title compound was synthesized (420 mg, 6%) following Description 6 from 1-(1,1-dimethylethyl) 2-methyl (2S)-5-oxo-1,2-pyrrolidinedicarboxylate (D5, 3.69 g, 15.2 mmol) and 3-bromophenyl phenylmethyl ether (D48); Rt (HPLC): 6.2 min.

Sources & evidence

ORD record
ord-ae7ce408891548879df1fc9728ef9202
Source dataset
uspto-grants-2010_12
Patent number
US07855218B2

Reaction notes

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