Methyl (2S)-5-(4-{[(2-fluorophenyl)methyl]amino}phenyl)-3,4-dihydro-2H-pyrrole-2-carboxylate → Methyl (5R)-5-(4-{[(2-fluorophenyl)methyl]amino}phenyl)-L-prolinate

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A solution of methyl (2S)-5-(4-{[(2-fluorophenyl)methyl]amino}phenyl)-3,4-dihydro-2H-pyrrole-2-carboxylate (D67, 39 mg, 0.119 mmol) and Pt 5% on carbon in ethyl acetate (10 ml) was stirred under 1 atm of hydrogen for 4.5 h, filtrated over celite and evaporated to afford the title compound (36 mg, 92%). MS: (ES/+) m/z: 329 [MH]+, —C19H21FN2O2 requires 328.

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