Acetyl chloride → HCID 59596677, compound

Participants

Reaction Steps

To a solution of methyl (2S)-5-(4-bromophenyl)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-pentynoate (D74, 1.199 g, 3.136 mmol) in dry EtOAc (18 ml) and dry methanol (2 ml) was added AcCl (1.14 ml, 1.25 g, 15.98 mmol). After solvent removal the residue was purified using a SCX cartridge affording the title compound (849 mg, 95%). UPLC: Rt 0.51 min, MS: (ES/+) m/z: 282, 284 [MH+], C12H12BrNO2 requires 282.

Provenance & Evidence