HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59596677, compound → methyl (2S)-5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59596677 | HCID 59596677 | — |
| Catalyst | Silver(I) trifluoromethanesulfonate | HCID 76223 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | methyl (2S)-5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole-2-carboxylate | HCID 59596717 | 103% |
Reaction Steps
A solution of methyl (2S)-2-amino-5-(4-bromophenyl)-4-pentynoate (D75, 849 mg, 3.009 mmol) and silver-(I)-triflate in acetonitrile (30 ml) was stirred overnight at room temperature. Then brine was added and the product was extracted with dichloromethane. The combined organic layers were dried (Na2SO4), filtered and evaporated to afford the title compound (874 mg, 96%). UPLC: Rt 0.70 min; MS: (ES/+) m/z: 282, 284 [MH+], C12H12BrNO2 requires 282.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855218B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-470589744cef4057b05d7ec205785450 |
| Source note | uspto-grants-2010_12 |