Hydrochloric Acid → HCID 68409375, compound

Participants

Reaction Steps

To a suspension of (5R)-5-[4-(2-phenylethyl)phenyl]-L-prolinamide (D81, 30 mg, 0.1 mmol) in diethyl ether (2 ml) was added hydrochloric acid (1N in Et2O, 150 μl) and the mixture was triturated. The solvent was removed under vacuum affording the title compound as a white solid (30 mg, 91%). Rt (HPLC): 3.81 min; MS: (ES/+) m/z: 295 [MH]+ C19H22N2O requires 294; 1H NMR (500 MHz, DMSO-d6) δ (ppm): 8.15-8.98 (br.s, 2H); 8.01 (s, 1H); 7.71 (s, 1H); 7.43 (d, 2H); 7.30 (d, 2H); 7.26 (d, 2H); 7.24 (t, 2H); 7.17 (t, 1H); 4.51-4.65 (m, 1H); 4.23-4.33 (m, 1H); 2.81-2.95 (m, 4H); 2.25-2.39 (m, 2H); 2.08-2.20 (m, 1H); 1.92-2.06 (m, 1H).

Provenance & Evidence