1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 11948186, compound

Participants

Reaction Steps

To a suspension of HOBt (30 mg, 0.20 mmol), EDCI (30 mg, 0.16 mmol), cyclopropyl amine (20 uL, 0.29 mmol) in DMF (0.5 mL) at RT was added 4-(5-carboxy-2-methoxy-phenylamino)-6-methyl-pyrrolo[1,2-d][1,2,4]triazine-7-carboxylic acid ethyl ester (13 mg, 0.035 mmol). The reaction was stirred overnight. Water (1 mL) was added and the precipitate collected. The product was purified by flash chromatography on silica gel (1-3% MeOH in CH2Cl2) giving the title compound, 7 mg, as a yellowish solid. HPLC (condition A) tR 4.37 min. MS m/z 410 [M+H]+.

Provenance & Evidence