Benzylamine → HCID 11949550, compound

Participants

Reaction Steps

To a solution of 4-(5-cyclopropylcarbamoyl-2-methyl-phenylamino)-6-methyl-pyrrolo[1,2-d][1,2,4]triazine-7-carboxylic acid (37, 0.13 mmol) in DMF (1 mL) was added EDCI (37 mg, 0.20 mmol), HOBt (30 mg, 0.20 mmol), Et3N (45 μL) and benzylamine (29 μl, 0.27 mmol). The reaction mixture was stirred for 3 h at rt. The crude material was purified by preparative HPLC to give the titled product, 3.3 mg as an off white solid. HPLC (condition A) tR 4.40 min. MS m/z 455 [M+H]+.

Provenance & Evidence