2-Chloro-9-[2-deoxy-3,5-di-o-(p-toluoyl)-beta-d-erythro-pentofuranosyl]-6-(2-isopropylimidazol-1-yl)purine → Purine

Participants

Reaction Steps

Benzylation of sterically hindered 6-(imidazol-1-yl)purines can result in mixtures of benzylated and nonbenzylated products such as when benzylating 2-chloro-9-[2-deoxy-3,5-di-O-p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(4,5-diphenylimidazol-1-yl)purine, 2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-isopropylimidazol-1-yl)purine. Partial decomposition can also result with 6-(2-benzylimidazol-1-yl)-2-chloro-9-[2-deoxy-3,5-di-O-p-toluoyl)-β-D-erythro-pentofuranosyl]purine.

Provenance & Evidence