Ethanol hydrochloride → HCID 86603828, compound

HRID 226490Notes

Reaction equation

HRID 226490 reaction equation
[ClH:1].CCO.[CH2:5]([N:12]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]2[N:23]=[C:22]([CH3:24])[C:21](/[CH:25]=[CH:26]/[C:27]([NH:29][O:30]C3CCCCO3)=[O:28])=[CH:20][N:19]=2)[CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CCO>[ClH:1].[ClH:1].[CH2:5]([N:12]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]2[N:23]=[C:22]([CH3:24])[C:21](/[CH:25]=[CH:26]/[C:27]([NH:29][OH:30])=[O:28])=[CH:20][N:19]=2)[CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 86603727HCID 86603727, compound

Product 1

HCID 86603828HCID 86603828, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
22.5 °C

Procedure

A solution of 2N HCl-EtOH solution (1.2 ml) was added to a mixture of (2E)-3-{2-[(1-benzyl-3-pyrrolidinyl)amino]-4-methyl-5-pyrimidinyl}-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (200 mg) in EtOH (5 ml) and stirred at 20-25° C. for 2 hours. IPE (30 ml) was added to a reaction mixture and the resultant mixture was stirred at ambient temperature for 20 minutes. The precipitate was collected by filtration to give (2E)-3-{2-[(1-benzyl-3-pyrrolidinyl)amino]-4-methyl-5-pyrimidinyl}-N-hydroxyacrylamide dihydrochloride (90 mg).

Workup

  1. additionIPE (30 ml) was added to a reaction mixture
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-06f004052da1433e9bf62c10758b19b8
Source dataset
uspto-grants-2009_07
Patent number
US07557127B2

Reaction notes

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