反应详情

A solution of 3-(4-cyclopropyl-2-fluoro-phenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester (197 mg, 0.50 mmol) and 1M NaOH (1.02 ml, 1.02 mmol) in IMS (3 ml) was heated at 60° C. for 2 hours. The reaction mixture was cooled to ambient temperature then acidified to pH 4 using acetic acid. The brown solid was filtered off, the residue dried to provide the title compound (161 mg, 97%). LCMS (method B): RT=2.18 min, M+H+=326.

1. filtrationThe brown solid was filtered off
2. customthe residue dried