HCID 15754624, compound → HCID 59679895, compound

Participants

Reaction Steps

2-(2-Nitro-phenyl)-imidazo[1,2-a]pyrimidine (2 g, 8.33 mmol) and NaHS (2.8 g, 6 eq) were refluxed in 25% aqueous methanol (40 ml) water overnight. The reaction mixture was cooled to room temperature, and concentrated to dryness. Methanol (10 ml) and water (30 ml) were added, and the product was extracted with CH2Cl2 (3×100 ml). The combined organic layers were concentrated to dryness, chased with 10% MeOH:CH2Cl2 and dried under high vacuum at 45° C. to obtain the product as an orange solid (1.34 g, 76% yield). (MS, M++H=211.1)

Provenance & Evidence