Methanol → HCID 86644275, compound

Participants

Reaction Conditions

Reaction Steps

Compound 5a (1.05 g), iron powder (1.11 g), and ammonium chloride (0.32 g) were added to a mixed solution of tetrahydrofuran (4 ml), methanol (4 ml), and water (4 ml). The mixture was stirred at 60° C. for 2 hours. The same amount of iron powder and ammonium chlorides were further added thereto, and the obtained mixture was stirred at 70° C. for 1 hour. After the reaction mixture was allowed to cool, and filtered, insoluble substances were filtered through Celite. The filtrate was condensed under reduced pressure to give Compound 5b (939 mg).

Provenance & Evidence