Hydrochloric Acid → HCID 68478089, compound

Participants

Reaction Steps

Compound 5c (304 mg) was dissolved in tetrahydrofuran (12 ml) and a 4.4% potassium hydroxide solution (8 ml) was added to the obtained mixture. The mixture was stirred at room temperature for 12 hours, and was further stirred under heating at 50° C. for 3 hours. The reaction mixture was allowed to cool, and a 2N hydrochloric acid aqueous solution was added thereto. The mixture was separated with ethyl acetate and water. The organic layer was sequentially washed once with a saturated sodium bicarbonate aqueous solution and once with a saturated sodium chloride solution, and then dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was recrystallized with a mixed solvent of diethyl ether and n-hexane to obtain Compound 5 (164 mg, 61%).

Provenance & Evidence