Ethyl 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-2-fluorocinnamate → (E)-Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-2,5-difluorophenyl]-2-butenoate

Participants

Reaction Steps

BTMB (800 mg) and Compound 10a (869 mg) were reacted in the same manner as Compound 2b was synthesized. After the reaction was over, the reaction mixture was separated with ethyl acetate and water. The organic layer was washed once with water and once with a saturated sodium chloride solution, and then dried over anhydrous sodium sulfate. The solvent was distilled off, and the residue was purified by column chromatography (5% ethyl acetate/n-hexane) to obtain Compound 10b (674 mg, 46%) as a light yellow solid.

Provenance & Evidence