HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl trans-crotonate → (E)-Ethyl 3-(4-amino-2-fluorophenyl)-2-butenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl trans-crotonate | HCID 429065 | — |
| Reactant | 4-Bromo-3-fluoroaniline | HCID 821848 | — |
| Reactant | (E)-Ethyl 3-(4-amino-2,5-difluorophenyl)-2-butenoate | HCID 86644278 | — |
| Product | (E)-Ethyl 3-(4-amino-2-fluorophenyl)-2-butenoate | HCID 86644280 | 17% |
Reaction Steps
Using 4-bromo-3-fluoroaniline (10.0 g) and ethyl crotonate (10.9 ml), Compound 11a (2.01 g, 17%) was obtained as a brown solid in the same manner as Compound 10a was synthesized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855300B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d3a9bcba01964541b2841b4ace09e521 |
| Source note | uspto-grants-2010_12 |