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(E)-Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-2,5-difluorophenyl]-2-butenoate → (E)-Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-2-fluorophenyl]-2-butenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (E)-Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-2,5-difluorophenyl]-2-butenoate | HCID 86644279 | — |
| 反応物 | (E)-Ethyl 3-(4-amino-2-fluorophenyl)-2-butenoate | HCID 86644280 | — |
| 生成物 | (E)-Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-2-fluorophenyl]-2-butenoate | HCID 86644281 | 42% |
反応手順
Using BTMB (1.0 g) and Compound 11a (1.01 g), Compound 11b (739 mg, 42%) was obtained as a light yellow solid in the same manner as Compound 10b was synthesized.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07855300B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-95f176e317d04ffdacb74ee4fc522eef |
| 出典メモ | uspto-grants-2010_12 |