HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-chloroaniline → (E)-Ethyl 3-(4-amino-2-chlorophenyl)-2-butenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-chloroaniline | HCID 88888 | — |
| Reactant | Ethyl trans-crotonate | HCID 429065 | — |
| Reactant | (E)-Ethyl 3-(4-amino-2,5-difluorophenyl)-2-butenoate | HCID 86644278 | — |
| Product | (E)-Ethyl 3-(4-amino-2-chlorophenyl)-2-butenoate | HCID 86644282 | 31% |
Reaction Steps
Using 4-bromo-3-chloroaniline (10.0 g) and ethyl crotonate (10.0 ml), Compound 12a (3.56 g, 31%) was obtained as a brown solid in the same manner as Compound 10a was synthesized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855300B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-91d8c67f60aa45309e8e81ba4677388e |
| Source note | uspto-grants-2010_12 |