反应详情

温度

120 °C

Compound 14b (14.6 mg) was dissolved in toluene (132 ml), and (carbetoxyethylidene)triphenylphosphorane (46.9 g) was added thereto. The obtained mixture was stirred under heating at 120° C. for 2 hours. After the reaction mixture was allowed to cool, n-heptane was added thereto and stirred. The precipitated solid was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was dissolved in methanol (125 ml), and purified water was added thereto. The precipitated solid was filtered off and then dried under reduced pressure. Thus, Compound 14c (17.3 g, 79%) was obtained as an opalescent solid.

1. temperatureto cool
2. stirringstirred
3. filtrationThe precipitated solid was filtered off
4. concentrationthe filtrate was concentrated under reduced pressure
5. dissolutionThe obtained residue was dissolved in methanol (125 ml)
6. custompurified water
7. additionwas added
8. filtrationThe precipitated solid was filtered off
9. customdried under reduced pressure