Hydrochloric Acid → HCID 25258036, compound

Participants

Reaction Conditions

Reaction Steps

Compound 14e (18.9 g) was dissolved in ethanol (302 ml), and a 2N sodium hydroxide aqueous solution (100 ml) was added thereto. The obtained mixture was stirred under heating at 50° C. for 2 hours. The reaction mixture was ice-cooled, and a 1N hydrochloric acid aqueous solution (300 ml) was added to neutralize the mixture. The precipitated solid was filtered off and dried under reduced pressure to obtain Crude Compound 14 (16.6 g) as a white solid. Crude Compound 14 (400 mg) was recrystallized with ethanol (4.0 ml) and purified water (4.0 ml) to obtain Compound 14 (344 mg, 86%) as a white solid.

Provenance & Evidence