Hydrochloric Acid → 4-[[3,5-Bis(trimethylsilyl)benzenecarbothioyl]amino]cinnamic acid

Participants

Reaction Steps

A 2N sodium hydroxide aqueous solution (6.99 ml) was added to an ethanol solution of Compound 17b (319 mg) in a nitrogen atmosphere. The obtained mixture was stirred at room temperature overnight. After the reaction was over, the reaction mixture was ice-cooled, and a 2N hydrochloric acid aqueous solution was added thereto. The precipitated solid was filtered off and recrystallized with a mixed solvent of n-hexane and ethyl acetate to obtain Compound 17 (183 mg, 61%) as a yellow solid.

Provenance & Evidence