HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 80854-57-5
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | p-Nitroacetophenone | HCID 7487 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Product | 80854-57-5 | HCID 6145404 | 29% |
Reaction Steps
A toluene (90 ml) solution of 4-nitroacetophenone (2.0 g) and (carbethoxymethylidene)triphenylphosphorane (6.33 g) was stirred while refluxing under heating for 10 hours. After the solution was allowed to cool, the solvent was distilled off. The obtained residue was purified by column chromatography (6.25% ethyl acetate/n-hexane) to obtain Compound 19a (829 mg, 29%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855300B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d698436e2133487c8add22e095a73a7e |
| Source note | uspto-grants-2010_12 |