HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzyl alcohol → 8-Benzyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzyl alcohol | HCID 72850 | — |
| Reactant | tert-Butyl 3-oxo-8-azabicyclo(3.2.1)octane-8-carboxylate | HCID 2794767 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | 3-Oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid benzyl ester | HCID 14682535 | — |
| Reactant | HCID 178418255 | HCID 178418255 | — |
| Product | 8-Benzyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol | HCID 13091224 | — |
Reaction Steps
2.80 g of the entitled compound was obtained as a white powder in the same manner as in Production Example 8-3, for which, however, benzyl 3-oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylate and phenylmagnesium bromide were used in place of tert-butyl 3-oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylate and the lithium reagent prepared from and 2-bromobenzyl alcohol and n-butyllithium-hexane solution used in Production Example 8-3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855294B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-f916fa7a41ed4e319eae749e6a9fe5c7 |
| Source note | uspto-grants-2010_12 |