Chloroform → HCID 86614354, compound

Participants

Reaction Conditions

Reaction Steps

At 0° C. 0.45 mL of triethylamine and 0.17 mL of methanesulfonyl chloride were added to chloroform (5 mL) solution of 237 mg of (3SR,4RS)-(1-methyl-4-o-tolylpiperidin-3-yl)-methanol obtained in Production Example 33-1. This was stirred at 0° C. for 50 minutes, diluted with ethyl acetate, washed with aqueous saturated sodium hydrogencarbonate solution, and dried with anhydrous sodium sulfate, and the solvent was evaporated off under reduced pressure to obtain 321 mg of 1-methyl-4-o-tolylpiperidin-3-ylmethyl methanesulfonate.

Provenance & Evidence