Benzyl Bromide → HCID 86614355, compound

Participants

Reaction Conditions

Reaction Steps

540 mg of potassium carbonate and 0.25 mL of benzyl bromide were added to N,N-dimethylformamide (7 mL) solution of 453 mg of methyl (3RS,4SR)-4-o-tolyl-piperidine-3-carboxylate obtained in Production Example 31, and stirred at 70° C. for 1.5 hours. Then, this was restored to room temperature, aqueous saturated sodium hydrogencarbonate solution was added thereto and extracted with ether. The ether layer was washed with saturated saline water, and dried with anhydrous sodium sulfate, and the solvent was evaporated off under reduced pressure. The residue was separated and purified through silica gel column chroamtography (hexane/ethyl acetate=9/1) to obtain 463 mg of methyl (3RS,4SR)-1-benzyl-4-o-tolyl-piperidine-3-carboxylate. The compound was processed in the same manner as in Production Example 33-1 to obtain 360 mg of the entitled compound.

Provenance & Evidence