2,2-Bis(4-chlorophenyl)ethanamine → 2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-N-[2,2-bis-(4-chloro-Phenyl)-ethyl]-4-chloro-benzamide

Participants

Role	Name	HCID	Charge
Reactant	2,2-Bis(4-chlorophenyl)ethanamine	HCID 13110442	—
Reactant	2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chlorobenzoic acid	HCID 16090663	—
Product	2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-N-[2,2-bis-(4-chloro-Phenyl)-ethyl]-4-chloro-benzamide	HCID 11534594	—

Reaction Steps

2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chlorobenzoic acid was coupled with 2,2-bis-(4-chloro-phenyl)-ethylamine as in EXAMPLE 1, Part C. HPLC: RT=11.40 min. MS (ESI−): mass calcd. for C27H19Cl3N4O3S2, 616.00; m/z found, 615/617 [M−H]−. 1H NMR (400 MHz, CDCl3): 11.49 (s, 1H), 8.36 (dd, J=7.1, 1.0, 1H), 8.23 (dd, J=8.8, 1.0, 1H), 7.72 (dd, J=8.8, 7.0, 1H), 7.68 (d, J=1.8, 1H), 7.34-7.30 (m, 4H), 7.18-7.13 (m, 4H), 6.89 (d, J=8.4, 1H), 6.86 (dd, J=8.4, 1.8, 1H), 5.87 (br t, J=5.6, 1H), 4.24 (t, J=8.0, 1H), 3.95 (dd, J=7.9, 5.9, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07855292B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-9891b4b9e4554b74ad146f169d854a3d
Source note	uspto-grants-2010_12