HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylboronic acid → 4-Methyl-2-[4'-trifluoromethyl-5-(4-trifluoromethyl-phenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 2-(5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57754941 | — |
| Product | 4-Methyl-2-[4'-trifluoromethyl-5-(4-trifluoromethyl-phenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester | HCID 57754985 | 43% |
Reaction Steps
The title compound was prepared in 43% yield from 2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 4-trifluoromethylphenylboronic acid under the conditions described in Example 15, step (g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557244B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-af9386626f764b5eba8080513255a1cb |
| Source note | uspto-grants-2009_07 |