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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 226520Generated: October 25, 2026

(4-Fluoro-3-methoxyphenyl)boronic acid → 2-[5-(4-Fluoro-3-methoxy-phenoxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

https://huagongshe.com/reaction/226520

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Fluoro-3-methoxyphenyl)boronic acidHCID 44558185—
Reactant2-(5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl esterHCID 57754941—
Product2-[5-(4-Fluoro-3-methoxy-phenoxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl esterHCID 5775492030%

Reaction Steps

The title compound was prepared in 30% yield from 2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 4-fluoro-3-methoxyphenylboronic acid under the conditions described in Example 15, step (g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557244B2
Source datasetuspto-grants-2009_07
ORD IDord-f831beafbbb943c7aeb9058f9ecbb984
Source noteuspto-grants-2009_07