3-(Trifluoromethyl)phenylboronic acid → 4-Methyl-2-[4'-trifluoromethyl-5-(3-trifluoromethyl-phenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester

HRID 226522Notes

Reaction equation

HRID 226522 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:12]=[C:13]([OH:15])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:27][C:28]([F:39])([F:38])[C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1>>[CH3:1][O:2][C:3](=[O:26])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:20][CH:21]=2)[CH:12]=[C:13]([O:15][C:33]2[CH:32]=[CH:31][CH:30]=[C:29]([C:28]([F:39])([F:38])[F:27])[CH:34]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 577549412-(5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester

Product 1

HCID 577550574-Methyl-2-[4'-trifluoromethyl-5-(3-trifluoromethyl-phenoxy)-biphenyl-3-yl]-pentanoic acid methyl esterYield 25%

Procedure

The title compound was prepared in 25% yield from 2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 3-trifluoromethylphenylboronic acid under the conditions described in Example 15, step (g).

Sources & evidence

ORD record
ord-d7feed9ccd264a52abd0da525a8f4c1f
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Reaction notes

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