2-Aminoindane → 2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chloro-N-indan-2-yl-benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Aminoindane	HCID 76310	—
Reactant	2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chlorobenzoic acid	HCID 16090663	—
Product	2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chloro-N-indan-2-yl-benzamide	HCID 11605478	—

Reaction Steps

2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chlorobenzoic acid was coupled with 2-aminoindane as in EXAMPLE 1, Part C. HPLC: RT=10.24 min. MS (ESI−): mass calcd. for C22H17ClN4O3S2, 484.04; m/z found, 483 [M−H]−. 1H NMR (400 MHz, CDCl3): 11.64 (s, 1H), 8.37 (dd, J=7.0, 1.0, 1H), 8.23 (dd, J=8.8, 1.0, 1H), 7.72 (dd, J=8.8, 7.0, 1H), 7.72 (d, J=2.0, 1H), 7.28-7.19 (m, 4H), 7.14 (d, J=8.4, 1H), 6.89 (dd, J=8.4, 2.0, 1H), 6.12 (br d, J=7.5, 1H), 4.87-4.80 (m, 1H), 3.41 (dd, J=16.3, 7.0, 2H), 2.83 (dd, J=16.3, 3.9, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07855292B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-69ad98e70b274651ab0b20d834533292
Source note	uspto-grants-2010_12