化工社化工社 化学情報印刷レポート · 研究参考用
3-Fluoro-5-(trifluoromethyl)benzeneboronic acid → 4-Methyl-2-[4'-chloro-3'-trifluoromethyl-5-(3-fluoro-5-trifluoromethylphenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluoro-5-(trifluoromethyl)benzeneboronic acid | HCID 2783192 | — |
| 反応物 | 2-(4'-Chloro-5-hydroxy-3'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57754927 | — |
| 生成物 | 4-Methyl-2-[4'-chloro-3'-trifluoromethyl-5-(3-fluoro-5-trifluoromethylphenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester | HCID 57754991 | 50% |
反応手順
The title compound was prepared in 50% yield from 2-(5-hydroxy-4′-chloro-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example A) and 3-fluoro-5-trifluoromethylphenylboronic acid under the conditions described in Example 15, step (g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557244B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-6b7fe30481664814b931d551f4724cb2 |
| 出典メモ | uspto-grants-2009_07 |