HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Difluorophenyl)boronic acid → 4-Methyl-2-[4'-chloro-3'-trifluoromethyl-5-(3,5-difluorophenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| Reactant | 2-(4'-Chloro-5-hydroxy-3'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57754927 | — |
| Product | 4-Methyl-2-[4'-chloro-3'-trifluoromethyl-5-(3,5-difluorophenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester | HCID 57754966 | 49% |
Reaction Steps
The title compound was prepared in 49% yield from 2-(5-hydroxy-4′-chloro-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example A) and 3,5-difluorophenylboronic acid under the conditions described in Example 15, step (g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557244B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-124eb20e6b2c411aaf0f962e273d4b4a |
| Source note | uspto-grants-2009_07 |