HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenylboronic acid → 2-[5-(4-Fluoro-phenoxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 2-(5-Hydroxy-4'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57754941 | — |
| Product | 2-[5-(4-Fluoro-phenoxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57754997 | 43% |
Reaction Steps
The title compound was prepared in 43% yield from 2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example 15, step (f)) and 4-fluorobenzeneboronic acid under the conditions described in Example 15, step (g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557244B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-3b062e1eb47049d088420716257781b1 |
| Source note | uspto-grants-2009_07 |