HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenylboronic acid → 2-[3'-Fluoro-5'-trifluoromethyl-5-(3-trifluoromethyl-phenoxy)-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenylboronic acid | HCID 2734388 | — |
| Reactant | 2-(3'-Fluoro-5-hydroxy-5'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57755035 | — |
| Product | 2-[3'-Fluoro-5'-trifluoromethyl-5-(3-trifluoromethyl-phenoxy)-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57755047 | 34% |
Reaction Steps
The title compound was prepared in 34% yield from 2-(3′-fluoro-5-hydroxy-5′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example B) and 3-trifluoromethylbenzene boronic acid under the conditions described in Example 15, step (g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557244B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-518151320cc04098b2325a71e0d30f01 |
| Source note | uspto-grants-2009_07 |