Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3,5-Difluorophenyl)boronic acid → 2-[5-(3,5-Difluoro-phenoxy)-3'-fluoro-5'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| 반응물 | 2-(3'-Fluoro-5-hydroxy-5'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57755035 | — |
| 생성물 | 2-[5-(3,5-Difluoro-phenoxy)-3'-fluoro-5'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57755053 | 83% |
반응 단계
The title compound was prepared in 83% yield from 2-(3′-fluoro-5-hydroxy-5′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example B) and 3,5-difluorobenzene boronic acid under the conditions described in Example 15, step (g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557244B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-01a35b7692924734897a0352d56111ee |
| 출처 메모 | uspto-grants-2009_07 |