2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid → HCID 10160535, compound

HRID 2265341Notes

Reaction equation

HRID 2265341 reaction equation
[O:1]=[C:2]1[CH2:11][CH:10]([C:12]([OH:14])=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[CH3:15][N:16]([CH3:34])[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:27][CH:26]=2)=[CH:19][CH:18]=1>>[CH3:15][N:16]([CH3:34])[C:17]1[CH:18]=[CH:19][C:20]([CH2:23][N:24]([C:25]2[CH:30]=[CH:29][C:28]([CH:31]([CH3:32])[CH3:33])=[CH:27][CH:26]=2)[C:12]([CH:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[NH:3][C:2](=[O:1])[CH2:11]2)=[O:14])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 5898502-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acidHCID 21957887N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine

Product 1

HCID 10160535HCID 10160535, compoundYield 52.1%

Procedure

By the reaction and treatment in the same manner as in Example 1 using 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid (0.5 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.7 g) as starting materials, N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxamide (0.6 g) was obtained. melting point: 170° C.

Sources & evidence

ORD record
ord-a62666950fa041efb09419f334a928ea
Source dataset
uspto-grants-2010_12
Patent number
US07855297B2

Reaction notes

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