HRID226542

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID719818

2,5-Bis(trifluoromethyl)aniline

C8H5F6N

结构：COC(=O)C(CC(C)C)c1cc(OS(=O)(=O)C(F)(F)F)cc(-c2cc(F)cc(C(F)(F)F)c2)c1

HCID57754925

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(CC(C)C)c1cc(Nc2cc(C(F)(F)F)ccc2C(F)(F)F)cc(-c2cc(F)cc(C(F)(F)F)c2)c1

HCID57755030

未命名化合物

收率 100%

PROCEDURE

实验过程

The title compound was prepared in 100% yield from 2-(5′-fluoro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 2,5-bis-(trifluoromethyl)aniline under the conditions described in Example 37, step (b).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-330a8005533c45cebbcc8911042eeee8
来源数据集: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07557244B2
来源说明: uspto-grants-2009_07

反应 SMILES

[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[C:25]([C:30]([F:33])([F:32])[F:31])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:35][C:36]([F:49])([F:48])[C:37]1[CH:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][C:38]=1[NH2:39]>>[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[C:25]([C:30]([F:32])([F:33])[F:31])[CH:24]=2)[CH:12]=[C:13]([NH:39][C:38]2[CH:40]=[C:41]([C:44]([F:45])([F:46])[F:47])[CH:42]=[CH:43][C:37]=2[C:36]([F:35])([F:48])[F:49])[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]