HRID2265438

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17854540

未命名化合物

HCID21957887

N,N-Dimethyl-4-{[4-(propan-2-yl)anilino]methyl}aniline

C18H24N2

PRODUCTS

生成物

结构：CC(C)c1ccc(N(Cc2ccc(N(C)C)cc2)C(=O)C2CCCc3c(OCc4ccccc4)ccc(F)c32)cc1

HCID59597364

未命名化合物

收率 79.6%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 12 using 5-benzyloxy-8-fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.5 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.45 g) as starting materials, 5-benzyloxy-N-[(4-dimethylaminophenyl)methyl]-8-fluoro-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.73 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7b906139dcbc4baf80f6cd66c20090f4
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07855297B2
来源说明: uspto-grants-2010_12

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:20](O)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][N:24]([CH3:42])[C:25]1[CH:30]=[CH:29][C:28]([CH2:31][NH:32][C:33]2[CH:38]=[CH:37][C:36]([CH:39]([CH3:41])[CH3:40])=[CH:35][CH:34]=2)=[CH:27][CH:26]=1>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:20]([N:32]([CH2:31][C:28]1[CH:27]=[CH:26][C:25]([N:24]([CH3:42])[CH3:23])=[CH:30][CH:29]=1)[C:33]1[CH:34]=[CH:35][C:36]([CH:39]([CH3:41])[CH3:40])=[CH:37][CH:38]=1)=[O:21])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1