Benzenamine, 3,5-bis(trifluoromethyl)- → 2-[5-(3,5-Bis-trifluoromethyl-phenylamino)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

HRID 226545Notes

Reaction equation

HRID 226545 reaction equation
[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:38][C:39]([F:52])([F:51])[C:40]1[CH:41]=[C:42]([CH:44]=[C:45]([C:47]([F:50])([F:49])[F:48])[CH:46]=1)[NH2:43]>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:30])([F:32])[F:31])[CH:26]=[C:25]([C:33]([F:34])([F:35])[F:36])[CH:24]=2)[CH:12]=[C:13]([NH:43][C:42]2[CH:44]=[C:45]([C:47]([F:48])([F:49])[F:50])[CH:46]=[C:40]([C:39]([F:38])([F:51])[F:52])[CH:41]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 577549144-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester

Product 1

HCID 577550012-[5-(3,5-Bis-trifluoromethyl-phenylamino)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl esterYield 47%

Procedure

The title compound was prepared in 47% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and 3,5-bis-trifluoromethyl-aniline under the conditions described in Example 37, step (b).

Sources & evidence

ORD record
ord-74db7bea23bd454a986cbcfb64e52ef1
Source dataset
uspto-grants-2009_07
Patent number
US07557244B2

Reaction notes

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