2,5-Bis(trifluoromethyl)aniline → 2-[5-(2,5-Bis-trifluoromethyl-phenylamino)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

HRID 226546Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 226546
[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:38][C:39]([F:52])([F:51])[C:40]1[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][C:41]=1[NH2:42]>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:30])([F:31])[F:32])[CH:26]=[C:25]([C:33]([F:34])([F:35])[F:36])[CH:24]=2)[CH:12]=[C:13]([NH:42][C:41]2[CH:43]=[C:44]([C:47]([F:48])([F:49])[F:50])[CH:45]=[CH:46][C:40]=2[C:39]([F:38])([F:51])[F:52])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Komponenten

3

Edukt 2

HCID 7198182,5-Bis(trifluoromethyl)anilineHCID 577549144-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester

Produkt 1

HCID 577550312-[5-(2,5-Bis-trifluoromethyl-phenylamino)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl esterAusbeute 39 %

Versuchsvorschrift

The title compound was prepared in 39% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Example 43, step (a)) and 2,5-bis-trifluoromethyl-aniline under the conditions described in Example 37, step (b).

Quellen und Nachweise

ORD-Eintrag
ord-954e1979797c4909819a8da2cd94a0b2
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557244B2

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