HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-(trifluoromethyl)aniline → 2-[5-(4-Fluoro-2-trifluoromethyl-phenylamino)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-(trifluoromethyl)aniline | HCID 67853 | — |
| Reactant | 4-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester | HCID 57754914 | — |
| Product | 2-[5-(4-Fluoro-2-trifluoromethyl-phenylamino)-3',5'-bis-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57755022 | 46% |
Reaction Steps
The title compound was prepared in 46% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Example 43, step (a)) and 4-fluoro-2-trifluoromethyl-aniline under the conditions described in Example 37, step (b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557244B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-28cfd4fe74b94b21a1db404a913060ba |
| Source note | uspto-grants-2009_07 |