Ethyl bromoacetate → HCID 59597444, compound

HRID 2265473Notes

Reaction equation

[CH2:1]([N:3]1[CH:7]=[C:6]([CH2:8][N:9]([C:23]2[CH:28]=[CH:27][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:25][CH:24]=2)[C:10]([CH:12]2[C:21]3[C:16](=[C:17]([OH:22])[CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14][CH2:13]2)=[O:11])[CH:5]=[N:4]1)[CH3:2].Br[CH2:33][C:34]([O:36][CH2:37][CH3:38])=[O:35]>>[CH2:1]([N:3]1[CH:7]=[C:6]([CH2:8][N:9]([C:23]2[CH:24]=[CH:25][C:26]([CH:29]([CH3:30])[CH3:31])=[CH:27][CH:28]=2)[C:10]([CH:12]2[CH2:13][CH2:14][CH2:15][C:16]3[C:17]([O:22][CH2:33][C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:18][CH:19]=[CH:20][C:21]2=3)=[O:11])[CH:5]=[N:4]1)[CH3:2]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 16679573HCID 16679573, compound

Product 1

HCID 59597444HCID 59597444, compound

Procedure

By the reaction and treatment in the same manner as in Example 106 using N-[(1-ethylpyrazol-4-yl)methyl]-5-hydroxy-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.00 g) and ethyl bromoacetate (0.40 mL) as starting materials, ethyl 2-(5-{N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)carbamoyl}-5,6,7,8-tetrahydronaphthalene-1-yloxy)acetate (1.09 g) was obtained.

Sources & evidence

ORD record: ord-1c32711eb5b044fc9759200f884faf6c
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07855297B2

Reaction notes

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