1,2,3,4-Tetrahydro-1-naphthoic acid → HCID 59597254, compound

HRID 2265480Notes

Reaction equation

HRID 2265480 reaction equation
[CH:1]1([C:11]([OH:13])=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH:14]([C:17]1[CH:22]=[CH:21][C:20]([NH:23][CH2:24][C:25]2[CH:26]=[N:27][N:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:29]=2)=[CH:19][CH:18]=1)([CH3:16])[CH3:15]>>[CH:14]([C:17]1[CH:18]=[CH:19][C:20]([N:23]([CH2:24][C:25]2[CH:26]=[N:27][N:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:29]=2)[C:11]([CH:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][CH2:2]2)=[O:13])=[CH:21][CH:22]=1)([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 125981461,2,3,4-Tetrahydro-1-naphthoic acidHCID 67182733HCID 67182733, compound

Product 1

HCID 59597254HCID 59597254, compoundYield 47%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.35 g) and (4-isopropylphenyl)[(1-phenylpyrazol-4-yl)methyl]amine (0.58 g) as starting materials, N-(4-isopropylphenyl)-N-[(1-phenylpyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.42 g) was obtained.

Sources & evidence

ORD record
ord-0ff51289aad8489fb179c1b3da096b1d
Source dataset
uspto-grants-2010_12
Patent number
US07855297B2

Reaction notes

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