HRID2265505

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12675261

2-(Chloromethyl)-4-methylpyridine

C7H8ClN

结构：CC(C)c1ccc(N(Cc2cn[nH]c2)C(=O)C2CCCc3c(OCc4ccccc4)ccc(F)c32)cn1.Cl

HCID67183347

未命名化合物

PRODUCTS

生成物

结构：Cc1ccnc(Cn2cc(CN(C(=O)C3CCCc4c(OCc5ccccc5)ccc(F)c43)c3ccc(C(C)C)nc3)cn2)c1

HCID59597420

未命名化合物

收率 84.2%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 271 using 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride (0.81 g) and 2-chloromethyl-4-methylpyridine (0.54 g) as starting materials, 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-N-({1-[(4-methylpyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.77 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-765a678568af4e34b2d8f6a639db8a0c
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07855297B2
来源说明: uspto-grants-2010_12

反应 SMILES

Cl.[CH2:2]([O:9][C:10]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]2[C:11]=1[CH2:12][CH2:13][CH2:14][CH:15]2[C:21]([N:23]([C:30]1[CH:31]=[N:32][C:33]([CH:36]([CH3:38])[CH3:37])=[CH:34][CH:35]=1)[CH2:24][C:25]1[CH:26]=[N:27][NH:28][CH:29]=1)=[O:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[CH2:40][C:41]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][N:42]=1>>[CH2:2]([O:9][C:10]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]2[C:11]=1[CH2:12][CH2:13][CH2:14][CH:15]2[C:21]([N:23]([C:30]1[CH:31]=[N:32][C:33]([CH:36]([CH3:38])[CH3:37])=[CH:34][CH:35]=1)[CH2:24][C:25]1[CH:29]=[N:28][N:27]([CH2:40][C:41]2[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][N:42]=2)[CH:26]=1)=[O:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1