HRID2265521

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17854147

未命名化合物

结构：Cc1ccc(OCc2ccccc2)c2c1C(C(=O)Nc1ccc(C(C)C)nc1)CCC2

HCID17854324

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(OCc2ccccc2)c2c1C(C(=O)N(Cc1cn[nH]c1)c1ccc(C(C)C)nc1)CCC2

HCID59191189

未命名化合物

收率 58.4%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 82 using 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-8-methyl-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.75 g) and 1-(tert-butyloxycarbonyl)-4-(hydroxymethyl)pyrazole (0.84 g) as starting materials, 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-8-methyl-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.22 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a1d25c37d21a4c5cb0cd477b2c6bff5b
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07855297B2
来源说明: uspto-grants-2010_12

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:20]([NH:22][C:23]1[CH:24]=[N:25][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:27][CH:28]=1)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC([N:39]1[CH:43]=[C:42]([CH2:44]O)[CH:41]=[N:40]1)=O)(C)(C)C>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:20]([N:22]([C:23]1[CH:24]=[N:25][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:27][CH:28]=1)[CH2:44][C:42]1[CH:43]=[N:39][NH:40][CH:41]=1)=[O:21])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1