HRID2265523

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15093928

(2-Ethyl-4-methyl-1,3-thiazol-5-yl)methanol

C7H11NOS

结构：CC(C)c1ccc(NC(=O)C2CCCc3c(OCc4ccccc4)cccc32)cn1

HCID17854215

未命名化合物

PRODUCTS

生成物

结构：CCc1nc(C)c(CN(C(=O)C2CCCc3c(OCc4ccccc4)cccc32)c2ccc(C(C)C)nc2)s1

HCID59597219

未命名化合物

收率 60.1%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 142 using 2-ethyl-5-hydroxymethyl-4-methylthiazole (0.63 g) and 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.8 g) as starting materials, 5-benzyloxy-N-[(2-ethyl-4-methylthiazol-5-yl)methyl]-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.3 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9c6567ed7c14c419e7ccbfef51b0c89
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07855297B2
来源说明: uspto-grants-2010_12

反应 SMILES

[CH2:1]([C:3]1[S:4][C:5]([CH2:9]O)=[C:6]([CH3:8])[N:7]=1)[CH3:2].[CH2:11]([O:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[CH2:21][CH2:22][CH2:23][CH:24]2[C:29]([NH:31][C:32]1[CH:33]=[N:34][C:35]([CH:38]([CH3:40])[CH3:39])=[CH:36][CH:37]=1)=[O:30])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([O:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[CH2:21][CH2:22][CH2:23][CH:24]2[C:29]([N:31]([CH2:9][C:5]1[S:4][C:3]([CH2:1][CH3:2])=[N:7][C:6]=1[CH3:8])[C:32]1[CH:33]=[N:34][C:35]([CH:38]([CH3:40])[CH3:39])=[CH:36][CH:37]=1)=[O:30])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1