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HRID 2265535作成日：2026年10月27日

1-Boc-4-(hydroxymethyl)pyrazole → 5-benzyloxy-N-(4-methoxyphenyl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide

https://huagongshe.com/reaction/2265535

反応式

関与物質

役割名称HCID仕込み量
反応物1-Boc-4-(hydroxymethyl)pyrazoleHCID 17854147—
反応物5-benzyloxy-N-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideHCID 17854517—
生成物5-benzyloxy-N-(4-methoxyphenyl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamideHCID 5959734348.4%

反応手順

By the reaction and treatment in the same manner as in Example 82 using 5-benzyloxy-N-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (2.98 g) and 1-(tert-butoxycarbonyl)-4-(hydroxymethyl)pyrazole (1.83 g) as starting materials, 5-benzyloxy-N-(4-methoxyphenyl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.74 g) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07855297B2
出典データセットuspto-grants-2010_12
ORD IDord-88292cc5e3fe419d8887b9698a980174
出典メモuspto-grants-2010_12