反应详情

To a solution of 1,1-cyclopropanedicarboxylic acid (3.12 g) in tetrahydrofuran (90 ml) was added dropwise triethylamine (2.43 g) while cooling in an ice water bath under a nitrogen atmosphere, followed by stirring for 1.5 hr. To the reaction mixture, was then added thionyl chloride (1.75 ml), followed by stirring at the same temperature for 30 min. To the reaction mixture were added 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxamide (2.97 g) and triethylamine (2.43 g) in this order while cooling in an ice water bath under a nitrogen atmosphere, followed by stirring for 70 min. The reaction mixture was partitioned after addition of tert-butyl methyl ether (30 ml) and a 1N aqueous solution of sodium hydroxide (90 ml). The aqueous layer was partitioned with tert-butyl methyl ether (30 ml) again, and the separated aqueous layer was treated with 1N hydrochloric acid to precipitate a solid. The solid was collected by suction filtration and washed with water (10 ml, four times). Drying under reduced pressure at 50° C. provided 1-[4-(2-carbamoylpyridin-4-yl)oxy-2-fluorophenylaminocarbonyl]cyclopropanecarboxylic acid as a pale purple solid (1.90 g, 44%). After the filtrate was stood overnight, further precipitated solid was collected by suction filtration and washed with water (10 ml, twice). Drying under reduced pressure provided additional 1-[4-(2-carbamoylpyridin-4-yl)oxy-2-fluorophenylaminocarbonyl]cyclopropanecarboxylic acid as a pale purple solid (758 mg, 18%).

1. temperaturewhile cooling in an ice water bath under a nitrogen atmosphere
2. stirringby stirring at the same temperature for 30 min
3. temperaturewhile cooling in an ice water bath under a nitrogen atmosphere
4. stirringby stirring for 70 min
5. customThe reaction mixture was partitioned
6. additionafter addition of tert-butyl methyl ether (30 ml)
7. customThe aqueous layer was partitioned with tert-butyl methyl ether (30 ml) again
8. additionthe separated aqueous layer was treated with 1N hydrochloric acid
9. customto precipitate a solid
10. filtrationThe solid was collected by suction filtration
11. washwashed with water (10 ml, four times)
12. customDrying under reduced pressure at 50° C.